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Changes Associated With H. Pylori and Gastric Carcinogenesis

September 9, 2019

Overview

This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it’s possible to intervene prior to this progression.

 

Study Information

Patients with prior or current active H. pylori infection who are planning to undergo endoscopic evaluation will be eligible for participation. From these patients, up to four additional biopsies from each area of stomach already being sampled will be taken. There will also be a small subset of patients without H. pylori enrolled as well, serving as a control group. 

The biopsies will be used for next-generation RNA and DNA sequencing and analyses. The analysis will be performed at Weill Cornell Medical College by Doron Betel, PhD. The sequencing will be performed in the Epigenetics Core laboratory under the supervision of Doron Betel.

This is an observational study with approximately 120 participants. It began in July 2012 and is estimated to conclude in April 2021.

 

Inclusion Criteria

  • Patient must be 18 years or older
  • Patient must have active or prior H. pylori infection, or have been treated for H.pylori infection in the past, as assessed by ELISA (not applicable for the subset of patient controls) or have gastric or esophageal cancer or have Barrett’s Esophagus
  • Patients must be eligible for and are planning to undergo a routine upper endoscopy and tissue biopsy
  • Patients must sign informed consent

 

Exclusion Criteria

  • Prior history of upper GI bleed (within 3 months)
  • Bleeding disorder or coagulopathy
  • Recent stroke or myocardial infarction (within 3 months)

 

Location

This study is taking place in the Weill Cornell Medical College in New York, United States. For further information contact Julianna Brouwer, MPH on 212-746-8539 or jub2024@med.cornell.edu.

 

Sponsors / Collaborators

This study is sponsored by the Weill Medical College of Cornell University, with Manish Shah, MD as the Principal Investigator.

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